BHRC Research Data Guide
Public aggregate summaries
12 BHRC polygenic score publications
Curated by: Lucas Toshio Ito - UNIFESP
lucas.toshio.ito@gmail.com
Literature reviewed through August 22, 2026
This page lists peer-reviewed publications verified as applying polygenic scores (PGS or PRS) in the Brazilian High-Risk Cohort for Mental Health Conditions (BHRC).
12.1 Publications
| Authors, year and link | Publication | Use of BHRC polygenic scores |
|---|---|---|
| Axelrud et al. (2018) | Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life | Alzheimer’s disease PGS evaluated in relation to memory performance and hippocampal volume. |
| Axelrud et al. (2019) | Genetic risk for Alzheimer’s disease and functional brain connectivity in children and adolescents | Alzheimer’s disease PGS evaluated in relation to resting-state functional connectivity. |
| Manfro et al. (2021) | Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents | ADHD, educational-attainment, and schizophrenia PGS used as external validators of an executive-dysfunction classification. |
| Navarro et al. (2021) | Polyenvironmental and polygenic risk scores and the emergence of psychotic experiences in adolescents | Psychotic-experience and schizophrenia PGS analyzed with environmental risk and adolescent psychotic experiences. |
| Salto et al. (2021) | Obsessive-Compulsive Symptoms, Polygenic Risk Score, and Thalamic Development in Children From the Brazilian High-Risk Cohort for Mental Conditions | Obsessive-compulsive disorder PGS analyzed with symptoms and longitudinal thalamic development. |
| Axelrud et al. (2023) | Disentangling the influences of parental genetics on offspring’s cognition, education, and psychopathology via genetic and phenotypic pathways | Parent and offspring PGS for cognition, education, ADHD, and schizophrenia used to examine intergenerational pathways. |
| Lorenzi et al. (2023) | Replication of a predictive model for youth ADHD in an independent sample from a developing country | ADHD PGS evaluated as an additional predictor in a longitudinal ADHD risk model. |
| Sato et al. (2023) | Polygenic risk score for attention-deficit/hyperactivity disorder and brain functional networks segregation in a community-based sample | ADHD PGS analyzed with symptoms and longitudinal functional-network segregation. |
| Leffa et al. (2024) | The synergistic effect of genetic and environmental factors in the development of attention-deficit/hyperactivity disorder symptoms in children and adolescents | ADHD PGS and an environmental risk score used to test gene-environment interaction. |
| Salto et al. (2025) | The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores | Multiple psychiatric PGS tested as predictors of longitudinal anxiety-symptom trajectories. |
| Doretto et al. (2024) | Childhood maltreatment and the structural development of hippocampus across childhood and adolescence | Hippocampal-volume PGS included as a genetic covariate in longitudinal structural analyses. |
| Duarte et al. (2025) | Enhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design | ADHD PGS evaluated alongside subcortical volumes and executive function. |
| Brañas, Ito et al. (2026) | Polygenic Risk for Major Depression: Diagnostic Specificity and Developmental Trajectories in an Admixed Youth Cohort | Major-depression PGS analyzed across diagnoses, depressive trajectories, symptoms, and nonsuicidal self-injury. |
| Damiano et al. (2026) | Developmental predictors of suicide attempts from childhood to early adulthood: a 15-year prospective cohort study | Five psychiatric and suicide-related PGS evaluated among developmental predictors of later suicide attempts. |
| Fonseca et al. (2026) | Executive function mediates the effects of genetic liability to schizophrenia on behavior and functioning in a community sample of children and adolescents | Schizophrenia PGS analyzed with executive function, psychopathology, and school performance. |
| Oliveira et al. (2026) | Moderating effects of childhood deprivation and threat on the relationship between polygenic score and internalizing symptoms: A longitudinal analysis | Internalizing-symptom PGS analyzed in interaction with childhood deprivation and threat. |
12.2 Database and methods resources
- BHRC Polygenic Score Database v3.0 - score construction, available phenotypes, ancestry principal components, relatedness, standardization, and analysis guidance.
- PGS Data Dictionary - score names, phenotypes, and source information.
- PRS-CS and PRS-CSx - primary score-construction methods used in the current database.
PGS associations in BHRC should be interpreted in light of ancestry mismatch, discovery-GWAS sample size, score version, relatedness, and the developmental stage of the cohort. See the PGS database documentation for analysis guidance.